The meandering of disordered proteins in conformational space
- PMID: 20399178
- DOI: 10.1016/j.str.2010.03.003
The meandering of disordered proteins in conformational space
Abstract
In this issue, Mittag et al. (2010) provided interesting insights concerning the molecular details of how the meandering of disordered proteins in conformational space can lead to collective binding modes and ultrasensitive probing of cellular kinase activities.
Copyright 2010 Elsevier Ltd. All rights reserved.
Comment on
-
Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase.Structure. 2010 Mar 14;18(4):494-506. doi: 10.1016/j.str.2010.01.020. Structure. 2010. PMID: 20399186 Free PMC article.
Similar articles
-
Atomistic details of the disordered states of KID and pKID. Implications in coupled binding and folding.J Am Chem Soc. 2009 Apr 15;131(14):5214-23. doi: 10.1021/ja808999m. J Am Chem Soc. 2009. PMID: 19278259
-
A FRET-based method for probing the conformational behavior of an intrinsically disordered repeat domain from Bordetella pertussis adenylate cyclase.Biochemistry. 2009 Dec 1;48(47):11273-82. doi: 10.1021/bi901447j. Biochemistry. 2009. PMID: 19860484
-
Role of backbone-solvent interactions in determining conformational equilibria of intrinsically disordered proteins.J Am Chem Soc. 2008 Jun 11;130(23):7380-92. doi: 10.1021/ja710446s. Epub 2008 May 16. J Am Chem Soc. 2008. PMID: 18481860
-
Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.Structure. 2009 Sep 9;17(9):1169-85. doi: 10.1016/j.str.2009.08.001. Structure. 2009. PMID: 19748338 Review.
-
Beauty is skin deep: the fascinating biology of the epidermis and its appendages.Harvey Lect. 1998-1999;94:47-77. Harvey Lect. 1998. PMID: 11070952 Review.
Cited by
-
Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin.Biochemistry. 2013 Aug 6;52(31):5167-75. doi: 10.1021/bi400502c. Epub 2013 Jul 24. Biochemistry. 2013. PMID: 23848319 Free PMC article.
-
Probing Local Backbone Geometries in Intrinsically Disordered Proteins by Cross-Correlated NMR Relaxation.Angew Chem Weinheim Bergstr Ger. 2013 Apr 22;125(17):4702-4704. doi: 10.1002/ange.201210005. Epub 2013 Mar 20. Angew Chem Weinheim Bergstr Ger. 2013. PMID: 25821254 Free PMC article. No abstract available.
-
Probing local backbone geometries in intrinsically disordered proteins by cross-correlated NMR relaxation.Angew Chem Int Ed Engl. 2013 Apr 22;52(17):4604-6. doi: 10.1002/anie.201210005. Epub 2013 Mar 20. Angew Chem Int Ed Engl. 2013. PMID: 23520002 Free PMC article.
-
How random are intrinsically disordered proteins? A small angle scattering perspective.Curr Protein Pept Sci. 2012 Feb;13(1):55-75. doi: 10.2174/138920312799277901. Curr Protein Pept Sci. 2012. PMID: 22044150 Free PMC article. Review.
-
IDPs: Less Disordered and More Ordered than Expected.Biophys J. 2015 Oct 6;109(7):1309-11. doi: 10.1016/j.bpj.2015.06.041. Biophys J. 2015. PMID: 26445429 Free PMC article. No abstract available.
Publication types
LinkOut - more resources
Full Text Sources