doi: 10.1016/j.bmcl.2010.03.109.
Epub 2010 Apr 2.
Clinical status of duplex RNA
Affiliations
- PMID: 20399650
- PMCID: PMC2874620
- DOI: 10.1016/j.bmcl.2010.03.109
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Clinical status of duplex RNA
Bioorg Med Chem Lett.
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Abstract
Double-stranded RNA has become a ubiquitous tool for inhibition of gene expression in the laboratory. If similar success could be achieved in vivo, duplex RNA might provide a new class of therapeutics capable of treating a broad spectrum of disease. Chemists and biologists developing duplex RNA as a drug have made progress but continue to face challenges. This review presents the current status of duplex RNA in the clinic and comments on future prospects for the approach.
Copyright 2010 Elsevier Ltd. All rights reserved.
Figures
(a) Structure of a typical siRNA. (b) Publications citing “siRNA” from 2001 to 2009.
Local and systemic siRNA drugs in clinical trials by year.
siRNA drugs in clinical trials classified by (top to bottom) target tissue, condition, and primary sponsoring company.
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