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. 2010 May;149(5):741-51.
doi: 10.1016/j.ajo.2010.01.009.

Four-year incidence and progression of age-related macular degeneration: the Los Angeles Latino Eye Study

Rohit Varma  1 , Athena W P Foong, Mei-Ying Lai, Farzana Choudhury, Ronald Klein, Stanley P Azen; Los Angeles Latino Eye Study Group
Collaborators, Affiliations

Four-year incidence and progression of age-related macular degeneration: the Los Angeles Latino Eye Study

Rohit Varma et al. Am J Ophthalmol. 2010 May.

Abstract

Purpose: To estimate 4-year incidence and progression of early and advanced age-related macular degeneration (AMD).

Design: Population-based cohort study.

Methods: A comprehensive ophthalmologic examination including stereoscopic fundus photography was performed on adult Latinos at baseline and follow-up. Photographs were graded using a modified Wisconsin Age-Related Maculopathy Grading System. For estimations of incidence and progression of AMD, the Age Related Eye Disease Study Scale was used. Main outcome measures are incidence and progression of early AMD (drusen type, drusen size, and retinal pigmentary abnormalities) and advanced AMD (exudative AMD and geographic atrophy).

Results: A total of 4658 of 6100 subjects (76%) completed the follow-up examination. The 4-year incidence of early AMD was 7.5% (95% CI: 6.7, 8.4) and advanced AMD was 0.2% (95% CI: 0.1, 0.4). Progression of any AMD occurred in 9.2% (95% CI: 8.3, 10.1) of at-risk participants. Incidence and progression increased with age. Incidence of early AMD in the second eye (11.2%) was higher than incidence in the first eye (6.9%). Baseline presence of soft indistinct large drusen >or=250 microm in diameter was more likely to predict the 4-year incidence of pigmentary abnormalities, geographic atrophy, and exudative AMD than smaller or hard or soft distinct drusen.

Conclusions: Age-specific incidence and progression of AMD in Latinos are lower than in non-Hispanic whites. While incident early AMD is more often unilateral, the risk of its development in the second is higher than in the first eye. Older people and those with soft indistinct large drusen had a higher risk of developing advanced AMD compared to those who were younger and did not have soft indistinct large drusen.

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Figures

Figure
Figure
Participation Flowchart for Assessing 4-Year Incidence and Progression of Age-Related Macular Degeneration (AMD) in the Los Angeles Latino Eye Study. *Photographs were not taken due to participant refusal, poor fixation or poor dilation. †Photographs were not gradable for AMD due to media opacities, poor camera focus, or other non-AMD conditions (e.g. diabetic macular edema) obscuring AMD lesions.
See this image and copyright information in PMC

References

    1. U.S. Interim Projections by Age, Sex, Race, and Hispanic Origin: U.S. Census Bureau, Population Division, Population Projections Branch. 2004.
    1. McKean-Cowdin R, Varma R, Wu J, Hays RD, Azen SP. Severity of visual field loss and health-related quality of life. Am J Ophthalmol. 2007;143:1013–23. - PMC - PubMed
    1. Varma R, Wu J, Chong K, Azen SP, Hays RD. Impact of severity and bilaterality of visual impairment on health-related quality of life. Ophthalmology. 2006;113:1846–53. - PubMed
    1. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104:7–21. - PubMed
    1. Mitchell P, Wang JJ, Foran S, Smith W. Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study. Ophthalmology. 2002;109:1092–7. - PubMed

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