Review
doi: 10.1016/S0065-230X(10)07005-3.
Androgen regulation of gene expression
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- PMID: 20399963
- DOI: 10.1016/S0065-230X(10)07005-3
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Review
Androgen regulation of gene expression
Adv Cancer Res.
2010.
Abstract
The biological action of androgenic male sex steroid hormones in prostate tissue is mediated by the androgen receptor, a nuclear transcription factor. The transcriptional program of androgenic signaling in the prostate consists of thousands of gene targets whose products play a role in almost all cellular functions, including cellular proliferation, survival, lipid metabolism, and differentiation. This review will provide a summary of the most recent data regarding androgen-regulated target genes and modulation of androgen receptor activity, especially with regard to androgen-dependent and castration-recurrent prostate cancer.
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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