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Review
. 2010 Jun;8(6):413-22.
doi: 10.1038/nrmicro2317. Epub 2010 Apr 19.

Behind the smile: cell biology and disease mechanisms of Giardia species

Johan Ankarklev  1 , Jon Jerlström-Hultqvist, Emma Ringqvist, Karin Troell, Staffan G Svärd
Affiliations
Review

Behind the smile: cell biology and disease mechanisms of Giardia species

Johan Ankarklev et al. Nat Rev Microbiol. 2010 Jun.

Abstract

The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.

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