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. 1998 Jul;3(4):246-50.
doi: 10.1093/pch/3.4.246.

Acetaminophen and ibuprofen in the management of fever and mild to moderate pain in children

H N McCullough  1
Affiliations

Acetaminophen and ibuprofen in the management of fever and mild to moderate pain in children

H N McCullough. Paediatr Child Health. 1998 Jul.

Abstract
in English, French

Acetaminophen has become the non-narcotic of choice for children because of concerns regarding the connection between acetylsalicylic acid exposure and Reye's syndrome. Ibuprofen, recently granted over-the-counter status for children over two years of age, offers another choice for treatment. The efficacy and safety of both drugs have been studied in numerous clinical trials. This paper reviews the published evidence about the efficacy and safety of acetaminophen and ibuprofen with regard to treating fever and mild to moderate pain in children.

L‘acétaminophène est devenu le non-narcotique d‘élection pour les enfants en raison des inquiétudes quant au lien entre l‘exposition à l‘acide acétylsalicilique et le syndrome de Reye. L‘ibuprofène, qui a récemment été autorisée en vente libre pour les enfants de plus de deux ans, constitue une autre possibilité de traitement. On a examiné l‘efficacité et l‘innocuité des deux médicaments dans de nombreuses études cliniques. Le présent article révise les observations publiées quant à l‘efficacité et à l‘innocuité de l‘acétaminophène et de l‘ibuprofène pour ce qui est du traitement de la fièvre et de la douleur bénigne à modérée chez l‘enfant.

Keywords: Acetaminophen; Fever; Ibuprofen; Pain.

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References

    1. Roberts NJ. Impact of temperature elevation on immunologic defenses. Rev Infect Dis. 1991;13:462–72. - PubMed
    1. Torrey SB, Henretig F, Fleisher G, et al. Temperature response to antipyretic therapy in children: Relationship to occult bacteremia. Am J Emerg Med. 1985;3:190–2. - PubMed
    1. Kramer MS, Naimark LE, Roberts-Brauer R, et al. Risks and benefits of paracetamol antipyresis in young children with fever of presumed viral origin. Lancet. 1991;337:591–4. - PubMed
    1. Baker MD, Fosarelli PD, Carpenter RO. Childhood fever: Correlation of diagnosis with temperature response to acetaminophen. Pediatrics. 1987;80:315–8. - PubMed
    1. Schnaiderman D, Lahat E, Sheefer T, Aladjem M. Antipyretic effectiveness of acetaminophen in febrile seizures: ongoing prophylaxis versus sporadic usage. Eur J Pediatr. 1993;152:747–9. - PubMed