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. 2011 Mar;15(1):63-6.
doi: 10.1007/s10006-010-0224-y.

Osteonecrosis of the jaw related to sunitinib

Felix P Koch  1 , Christian Walter, Torsten Hansen, Elke Jäger, Wilfried Wagner
Affiliations

Osteonecrosis of the jaw related to sunitinib

Felix P Koch et al. Oral Maxillofac Surg. 2011 Mar.

Abstract

Case report: A 59-year-old male patient was referred to the hospital with exposed bone measuring 10 mm in diameter in the posterior, left-side region of the lower jaw. Two months previous, the first molar had been extracted. The patient had contracted renal cell carcinoma and had been treated by nephrectomy in 2003. Soft tissue metastases occurred. After initial therapy with interferon and vinblastine, a relapse occurred and the therapy was changed to sorafenib, followed by sunitinib. Osteonecrosis of the lower jaw appeared 1 year after initial and exclusive therapy with sunitinib.

Conclusions: Bisphosphonates had never been applied. With increasing application of multi-kinase inhibitors, complications due to osteonecrosis could occur more frequently.

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