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. 2010 Jun 1;201(11):1703-7.
doi: 10.1086/652419.

African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy

Jeffrey A Canter  1 , Gregory K Robbins, Doug Selph, David B Clifford, Asha R Kallianpur, Robert Shafer, Shawn Levy, Deborah G Murdock, Marylyn D Ritchie, David W Haas, Todd Hulgan; AIDS Clinical Trials Group Study 384 Team; New Work Concept Sheet 273 Team
Affiliations

African mitochondrial DNA subhaplogroups and peripheral neuropathy during antiretroviral therapy

Jeffrey A Canter et al. J Infect Dis. .

Abstract

Susceptibility to peripheral neuropathy during antiretroviral therapy with nucleoside reverse-transcriptase inhibitors was previously associated with a European mitochondrial DNA (mtDNA) haplogroup among non-Hispanic white persons. To determine whether nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy was related to mtDNA variation in non-Hispanic black persons, we sequenced mtDNA of participants from AIDS Clinical Trials Group study 384. Of 156 non-Hispanic black persons with genomic data, 51 (33%) developed peripheral neuropathy. In a multivariate model, African mtDNA subhaplogroup L1c was an independent predictor of peripheral neuropathy (odds ratio, 3.7 [95% confidence interval, 1.1-12.0]). An African mtDNA subhaplogroup is for the first time implicated in susceptibility to nucleoside reverse-transcriptase inhibitor-associated toxicity.

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