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Comment
. 2010 Apr 27;107(17):7625-6.
doi: 10.1073/pnas.1002943107. Epub 2010 Apr 19.

Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver

Selena M Sagan  1 , Peter Sarnow
Affiliations
Comment

Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver

Selena M Sagan et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Secretion of IFN by pDCs after contact with HCV-infected hepatocytes. HCV-infected cells recognize viral RNA and signal through cellular sensors of foreign RNA, RIG-I, and TLR3 to induce synthesis of IFN and ISGs. In response, HCV evades the IFN response by virally encoded protease (NS3/4A) that cleaves key molecules involved in RIG-I and TLR3 signaling, thereby effectively turning off production of IFN and ISGs in infected hepatocytes. Through a cell contact–dependent mechanism, viral RNA is transferred from infected hepatocytes to infiltrating pDCs. pDCs recognize viral RNA through endosomal TLR7, resulting in the synthesis of ISGs and secretion of large amounts of IFN to surrounding hepatocytes.
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