Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2010 Apr 27;107(17):7625-6.
doi: 10.1073/pnas.1002943107. Epub 2010 Apr 19.

Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver

Selena M Sagan  1 , Peter Sarnow
Affiliations
Comment

Plasmacytoid dendritic cells as guardians in hepatitis C virus-infected liver

Selena M Sagan et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Secretion of IFN by pDCs after contact with HCV-infected hepatocytes. HCV-infected cells recognize viral RNA and signal through cellular sensors of foreign RNA, RIG-I, and TLR3 to induce synthesis of IFN and ISGs. In response, HCV evades the IFN response by virally encoded protease (NS3/4A) that cleaves key molecules involved in RIG-I and TLR3 signaling, thereby effectively turning off production of IFN and ISGs in infected hepatocytes. Through a cell contact–dependent mechanism, viral RNA is transferred from infected hepatocytes to infiltrating pDCs. pDCs recognize viral RNA through endosomal TLR7, resulting in the synthesis of ISGs and secretion of large amounts of IFN to surrounding hepatocytes.
See this image and copyright information in PMC

Comment on

References

    1. Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805–820. - PubMed
    1. Wilkins C, Gale M., Jr Recognition of viruses by cytoplasmic sensors. Curr Opin Immunol. 2010;22:41–47. - PMC - PubMed
    1. Moradpour D, Penin F, Rice CM. Replication of hepatitis C virus. Nat Rev Microbiol. 2007;5:453–463. - PubMed
    1. Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest. 2009;119:1745–1754. - PMC - PubMed
    1. Bigger CB, et al. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol. 2004;78:13779–13792. - PMC - PubMed

Substances