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. 2010 Apr;17(2):59-63.
doi: 10.3747/co.v17i2.453.

Evaluation of six risk factors for the development of bacteremia in children with cancer and febrile neutropenia

E J Asturias  1 , J E Corral, J Quezada
Affiliations

Evaluation of six risk factors for the development of bacteremia in children with cancer and febrile neutropenia

E J Asturias et al. Curr Oncol. 2010 Apr.

Abstract

Febrile neutropenia is a well-known entity in children with cancer, being responsible for the high risk for infection that characterizes this population. For this reason, cancer patients are hospitalized so that they can receive prophylactic care. Risk factors have been used to classify patients at a high risk for developing bacteremia. The present study evaluates whether those risk factors (C-reactive protein, hypotension, leukemia as the cancer type, thrombocytopenia, recent chemotherapy, and acute malnutrition) apply to patients at the Unidad Nacional de Oncología Pediátrica. We evaluated 102 episodes in 88 patients, in whom risk factors and blood cultures were tested. We observed no statistical relationship between the six risk factors and bacteremia. There was also no relationship between bacteremia and the simultaneous presence of two, three, or more risk factors. A significant relationship of C-reactive protein and platelet count with other outcome factors was observed.

Keywords: C-reactive protein; Cancer; bacteremia; fever; leukemia; neutropenia; risk factors; thrombocytopenia.

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References

    1. Tamburro R. Pediatric cancer patients in clinical trials of sepsis: factors that predispose to sepsis and stratify outcome. Pediatr Crit Care Med. 2005;6(suppl):S87–91. - PubMed
    1. Pizzo PA. Fever in immunocompromised patients. N Engl J Med. 1999;341:893–900. - PubMed
    1. Allen UD. Factors influencing predisposition to sepsis in children with cancers and acquired immunodeficiencies unrelated to human immunodeficiency virus infection. Pediatr Crit Care Med. 2005;6(suppl):S80–6. - PubMed
    1. Santolaya ME, Alvarez AM, Becker A. Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever. J Clin Oncol. 2001;19:3415–21. - PubMed
    1. Castagnola E, Viscoli C, Bernaola E. Complicaciones infecciosas en el niño con enfermedad hematooncológica. In: Sierrasesúmaga L, Antillón Klussmann F, editors. Tratado de Oncología Pediátrica. Madrid: Pearson Educación S.A; 2006. pp. 755–84.