doi: 10.1021/ol1006086.
Highly enantioselective relay catalysis in the three-component reaction for direct construction of structurally complex heterocycles
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- PMID: 20405953
- DOI: 10.1021/ol1006086
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Highly enantioselective relay catalysis in the three-component reaction for direct construction of structurally complex heterocycles
Org Lett.
.
Abstract
A highly enantioselective three-component cascade reaction, consisting of an enantioselective [4+2] cycloaddition reaction catalyzed by chiral phosphoric acid and a subsequent catalytic intramolecular hydroamination by gold(I) complex, provides a unique method to access structurally diverse julolidine derivatives in high optical purity.
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