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Comparative Study
. 1991 Jun 15;266(17):11234-6.

Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

E A Lerner  1 , J M Ribeiro, R J Nelson, M R Lerner
Affiliations
  • PMID: 2040631
Free article
Comparative Study

Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

E A Lerner et al. J Biol Chem. .
Free article

Abstract

Blood feeding by the sand fly Lutzomyia longipalpis is aided by the presence of a vasodilator in its salivary glands. This novel vasodilator has been isolated by reversed-phase high-performance liquid chromatography. Ten nanograms of the vasodilator are present in the extract of a pair of sand fly salivary glands. It has 500 times the vasodilatory activity of calcitonin gene-related peptide, previously the most potent vasodilator peptide known. This novel peptide is thus called maxadilan.

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