Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 May;19(5):1349-55.
doi: 10.1158/1055-9965.EPI-09-1181. Epub 2010 Apr 20.

Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2

Ludmila Prokunina-Olsson  1 , Yi-Ping Fu, Wei Tang, Kevin B Jacobs, Richard B Hayes, Peter Kraft, Sonja I Berndt, Sholom Wacholder, Kai Yu, Amy Hutchinson, Heather Spencer Feigelson, Michael J Thun, W Ryan Diver, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Fredrick R Schumacher, Geraldine Cancel-Tassin, Olivier Cussenot, Antoine Valeri, Gerald L Andriole, E David Crawford, Christopher A Haiman, Brian E Henderson, Laurence Kolonel, Loic Le Marchand, Afshan Siddiq, Elio Riboli, Ruth Travis, Rudolf Kaaks, William B Isaacs, Sarah D Isaacs, Henrik Grönberg, Fredrik Wiklund, Jianfeng Xu, Lars J Vatten, Kristian Hveem, Merethe Kumle, Margaret Tucker, Robert N Hoover, Joseph F Fraumeni Jr, David J Hunter, Gilles Thomas, Nilanjan Chatterjee, Stephen J Chanock, Meredith Yeager
Affiliations
Comparative Study

Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2

Ludmila Prokunina-Olsson et al. Cancer Epidemiol Biomarkers Prev. 2010 May.

Abstract

Background: Genome-wide association studies have identified multiple genetic variants associated with susceptibility to prostate cancer (PrCa). In the two-stage Cancer Genetic Markers of Susceptibility prostate cancer scan, a single-nucleotide polymorphism (SNP), rs10486567, located within intron 2 of JAZF1 gene on chromosome 7p15.2, showed a promising association with PrCa overall (P=2.14x10(-6)), with a suggestion of stronger association with aggressive disease (P=1.2x10(-7)).

Methods: In the third stage of genome-wide association studies, we genotyped 106 JAZF1 SNPs in 10,286 PrCa cases and 9,135 controls of European ancestry.

Results: The strongest association was observed with the initial marker rs10486567, which now achieves genome-wide significance [P=7.79x10(-11); ORHET, 1.19 (95% confidence interval, 1.12-1.27); ORHOM, 1.37 (95% confidence interval, 1.20-1.56)]. We did not confirm a previous suggestion of a stronger association of rs10486567 with aggressive disease (P=1.60x10(-4) for aggressive cancer, n=4,597; P=3.25x10(-8) for nonaggressive cancer, n=4,514). Based on a multilocus model with adjustment for rs10486567, no additional independent signals were observed at chromosome 7p15.2. There was no association between PrCa risk and SNPs in JAZF1 previously associated with height (rs849140; P=0.587), body stature (rs849141, tagged by rs849136; P=0.171), and risk of type 2 diabetes and systemic lupus erythematosus (rs864745, tagged by rs849142; P=0.657).

Conclusion: rs10486567 remains the most significant marker for PrCa risk within JAZF1 in individuals of European ancestry.

Impact: Future studies should identify all variants in high linkage disequilibrium with rs10486567 and evaluate their functional significance for PrCa.

PubMed Disclaimer

Figures

Figure 1
Figure 1
LD structure and association results for 106 SNPs distributed over 275 Kb covering 25 Kb of promoter region through part of intron 2 of JAZF1 gene. LD plot is based on all samples (10,286 prostate cancer patients and 9,135 controls) of European ancestry.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Pooled sample-based GWAS: a cost-effective alternative for identifying colorectal and prostate cancer risk variants in the Polish population.
    Gaj P, Maryan N, Hennig EE, Ledwon JK, Paziewska A, Majewska A, Karczmarski J, Nesteruk M, Wolski J, Antoniewicz AA, Przytulski K, Rutkowski A, Teumer A, Homuth G, Starzyńska T, Regula J, Ostrowski J. Gaj P, et al. PLoS One. 2012;7(4):e35307. doi: 10.1371/journal.pone.0035307. Epub 2012 Apr 19. PLoS One. 2012. PMID: 22532847 Free PMC article.
  • Validation of genome-wide prostate cancer associations in men of African descent.
    Chang BL, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel AS, Thompson IM, Leach RJ, Ostrander EA, Stanford JL, Witte J, Casey G, Eeles R, Hsing AW, Chanock S, Hu JJ, John EM, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck TR. Chang BL, et al. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23-32. doi: 10.1158/1055-9965.EPI-10-0698. Epub 2010 Nov 11. Cancer Epidemiol Biomarkers Prev. 2011. PMID: 21071540 Free PMC article.
  • Genome-wide association study identifies new prostate cancer susceptibility loci.
    Schumacher FR, Berndt SI, Siddiq A, Jacobs KB, Wang Z, Lindstrom S, Stevens VL, Chen C, Mondul AM, Travis RC, Stram DO, Eeles RA, Easton DF, Giles G, Hopper JL, Neal DE, Hamdy FC, Donovan JL, Muir K, Al Olama AA, Kote-Jarai Z, Guy M, Severi G, Grönberg H, Isaacs WB, Karlsson R, Wiklund F, Xu J, Allen NE, Andriole GL, Barricarte A, Boeing H, Bueno-de-Mesquita HB, Crawford ED, Diver WR, Gonzalez CA, Gaziano JM, Giovannucci EL, Johansson M, Le Marchand L, Ma J, Sieri S, Stattin P, Stampfer MJ, Tjonneland A, Vineis P, Virtamo J, Vogel U, Weinstein SJ, Yeager M, Thun MJ, Kolonel LN, Henderson BE, Albanes D, Hayes RB, Feigelson HS, Riboli E, Hunter DJ, Chanock SJ, Haiman CA, Kraft P. Schumacher FR, et al. Hum Mol Genet. 2011 Oct 1;20(19):3867-75. doi: 10.1093/hmg/ddr295. Epub 2011 Jul 8. Hum Mol Genet. 2011. PMID: 21743057 Free PMC article.
  • Gene-environment interactions between JAZF1 and occupational and household lead exposure in prostate cancer among African American men.
    Neslund-Dudas C, Levin AM, Beebe-Dimmer JL, Bock CH, Nock NL, Rundle A, Jankowski M, Krajenta R, Dou QP, Mitra B, Tang D, Rebbeck TR, Rybicki BA. Neslund-Dudas C, et al. Cancer Causes Control. 2014 Jul;25(7):869-79. doi: 10.1007/s10552-014-0387-1. Epub 2014 May 7. Cancer Causes Control. 2014. PMID: 24801046 Free PMC article.
  • Prostate Cancer Related JAZF1 Gene is Associated with Schizophrenia.
    Wang KS, Zuo L, Owusu D, Pan Y, Luo X. Wang KS, et al. J Schizophr Res. 2014;1(1):1002. Epub 2014 Aug 1. J Schizophr Res. 2014. PMID: 27570842 Free PMC article.
See all "Cited by" articles

References

    1. Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007;18:581–592. - PubMed
    1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin. 2009;59:225–249. - PubMed
    1. Crawford ED. Epidemiology of prostate cancer. Urology. 2003;62:3–12. - PubMed
    1. Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343:78–85. - PubMed
    1. Shteynshlyuger A, Andriole GL. Prostate Cancer: To Screen or Not to Screen? Urol Clin North Am. 37:1–9. - PubMed

Publication types