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. 2009 Summer;6(2):41-45.
doi: 10.1016/j.ddmod.2009.03.008.

Mouse Models for Type 1 Diabetes

T L Van Belle  1 , P Taylor, M G von Herrath
Affiliations

Mouse Models for Type 1 Diabetes

T L Van Belle et al. Drug Discov Today Dis Models. 2009 Summer.

Abstract

Our understanding of the genetics, aetiology and pathogenesis of Type 1 Diabetes (T1D) was propelled by the discovery of animal models of T1D in the late 1970s and early 1980s, particularly the non-obese diabetic (NOD) mouse. Since then, transgenic and gene-targeting technologies allowed the generation of many models with reduced genetic and pathogenic complexity. These models allowed researchers to zoom in on specific aspects of this complex disease. In this review, we provide an overview of currently available mouse models for T1D.

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Figures

Figure 1
Figure 1. Pathogenesis of Type I diabetes
Initial β-cell damage or death (1) releases antigens (2), including auto-antigens (in red, e.g. insulin, GAD65), which are presented by antigen-presenting cells (APC) in the lymph nodes draining the pancreas (3). Priming of auto-reactive effector T cells occurs only in susceptible individuals by an environmental triggers leading to an unbalanced immune response. Auto-aggressive T cells migrate to the pancreas (4) and start destroying the β-cells in the islets of Langerhans (5).
See this image and copyright information in PMC

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