The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review
- PMID: 20407608
- PMCID: PMC2855634
The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review
Abstract
Alcohol dependence is believed to be a multifactorial, polygenic disorder involving complex gene-gene and gene-environment interactions and confounded by heterogeneity and sociocultural factors. Serotonin (5-Hydroxytryptamine, 5-HT) is thought to be involved in many aspects of alcohol consumption, abuse, and dependence. There was some evidence that serotonin-related genes might interact with the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol dependence. In the current review, we discuss the role of serotonin and possible interaction of serotonin-related genes with ADH and ALDH genes in alcohol dependence.
Keywords: 5-HT; ADH; ALDH; Alcohol dependence; gene-gene interaction; serotonin-related genes.
Figures
Similar articles
-
Association and ancestry analysis of sequence variants in ADH and ALDH using alcohol-related phenotypes in a Native American community sample.Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):673-83. doi: 10.1002/ajmg.b.32272. Epub 2014 Sep 30. Am J Med Genet B Neuropsychiatr Genet. 2014. PMID: 25270064 Free PMC article.
-
Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis.Exp Mol Pathol. 2011 Oct;91(2):631-5. doi: 10.1016/j.yexmp.2011.06.008. Epub 2011 Jul 23. Exp Mol Pathol. 2011. PMID: 21798257
-
Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.Alcohol Clin Exp Res. 2018 Dec;42(12):2281-2297. doi: 10.1111/acer.13904. Epub 2018 Nov 11. Alcohol Clin Exp Res. 2018. PMID: 30320893 Free PMC article. Review.
-
Influence of genetic variation in alcohol and aldehyde dehydrogenase on serotonin metabolism.Life Sci. 1994;55(5):359-66. doi: 10.1016/0024-3205(94)00646-6. Life Sci. 1994. PMID: 8035649
-
Alcohol dependence and gene x environment interaction in emotion regulation: Is serotonin the link?Eur J Pharmacol. 2005 Dec 5;526(1-3):113-24. doi: 10.1016/j.ejphar.2005.09.027. Epub 2005 Nov 8. Eur J Pharmacol. 2005. PMID: 16288736 Review.
Cited by
-
Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats.Part Fibre Toxicol. 2020 Jan 29;17(1):7. doi: 10.1186/s12989-019-0335-z. Part Fibre Toxicol. 2020. PMID: 31996220 Free PMC article.
References
-
- Cloninger CR. Neurogenic adaptive mechanisms in alcoholism. Science. 1987;236:410–416. - PubMed
-
- Goldman D. Genetic transmission, in Recent Developments in Alcoholism. In: Galanter M, editor. Vol. 11. New York: Plenum Press; 1993. pp. 231–248. - PubMed
-
- Dick DM, Foroud T. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. Alcohol Clin Exp Res. 2003;27(5):868–79. - PubMed
-
- Merikangas KR. The genetic epidemiology of alcoholism. Psychol Med. 1990;20:11–22. - PubMed
-
- Cadoret RJ, Cain CA, Grove WM. Developmental alcoholism in adopted raise apart from alcoholic biological relatives. Arch Gen Psychiatry. 1980;37:561–3. - PubMed
LinkOut - more resources
Full Text Sources