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. 2009 Jan;15(1):3-8.
doi: 10.4103/0971-6866.50862.

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Nitya G Chakraborty  1
Affiliations

Immunoregulation through IL-10 gene expression and the fate of cytotoxic T lymphocyte-mediated tumor immunotherapy

Nitya G Chakraborty. Indian J Hum Genet. 2009 Jan.

Abstract

Gene analysis of tumor associated antigens revealed that tumor antigens are all normal gene product. Inducing tumor reactive cytotoxic T lymphocytes (CT) in the patients is same as inducing autoimmunity in the patients. Immunosuppressive cytokine interleukin-10 (IL-10) plays an important role in maintaining homeostasis or tolerance. To break the tumor tolerance, blocking and IL-10 secretion or intervention in the pathways of IL-10 gene activation is indeed important.

Keywords: Cytotoxic T Lymphocyte (CTL) Regulatory T cells (Tregs); Interleukin-10 (IL-10); Tumor antigens.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Vaccine induced CTL response
Figure 2
Figure 2
Innate and adaptive Immune response and the corresponding gene expressions
See this image and copyright information in PMC

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