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. 2009 Jan;15(1):9-12.
doi: 10.4103/0971-6866.50863.

Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran

Hamid Galehdari  1 , Ali Mohammad Foroughmand, Maryam Naderi Soorki, Gholamreza Mohammadian
Affiliations

Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran

Hamid Galehdari et al. Indian J Hum Genet. 2009 Jan.

Abstract

Background: The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins.

Materials and methods: We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.

Result: None of the analyzed samples revealed deafness-associated mutation.

Conclusion: This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.

Keywords: Connexin 26; GJB2; Iranian Arabs; nonsyndromic autosomal recessive deafness.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
GJB2 mutation passage through Iran[14]
See this image and copyright information in PMC

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References

    1. Kelsell DP, Dunlop J, Stevens HP, Lench NJ, Liang JN, Parry G, et al. Connexin 26 mutations in hereditary non-syndromic sensorineural deafness. Nature. 1997;387:80–3. - PubMed
    1. Morton NE. Genetic epidemiology of hearing impairment. Ann N Y Acad Sci. 1991;630:16–31. - PubMed
    1. Skvorak Giersch AB, Morton CC. Genetic causes of non-syndromic hearing loss. Curr Opin Pediatr. 1999;11:551–7. - PubMed
    1. Storm K, Wilcox S, Flothmann K, van Camp G. Determination of the carrier frequency of the common GJB2 (connexin) 35delG mutation in the Belgian population using an easy and reliable screening method. Hum Mutat. 1999;14:263–6. - PubMed
    1. Cohn ES, Kelley PM. Clinical phenotype and mutations in connexin 26 (DFNB1/GJB2), the most common cause of childhood hearing loss. Am J Med Genet. 1999;89:130–6. - PubMed