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. 2009 May;13(2):64-8.
doi: 10.4103/0972-124X.55837.

Anticytokine therapy for periodontal diseases: Where are we now?

Yogesh Prakash Waykole  1 , S S Doiphode, P S Rakhewar, Maya Mhaske
Affiliations

Anticytokine therapy for periodontal diseases: Where are we now?

Yogesh Prakash Waykole et al. J Indian Soc Periodontol. 2009 May.

Abstract

Periodontal destruction is initiated by bacteria that stimulate host responses leading to excess production of cytokines. Anticytokine therapy for periodontal diseases especially targets proinflammatory cytokines, that is, TNF-alpha, IL-1, and IL-6, because these are essential for the initiation of the inflammatory immune reaction and are produced for prolonged periods in periodontitis. This therapy aims to bind the cytokines with the receptors present on target cells such as the fibroblasts. The three basic treatment strategies are: (1) neutralization of cytokines, (2) blockage of cytokine receptors, and (3) activation of anti-inflammatory pathways, such as, immune-suppressive pathways.This new therapy can act as a host response modulator in the control of inflammatory diseases of gums and may provide the basis for new molecular therapeutic approaches to the treatment of periodontitis.

Keywords: IL-1; IL-6; TNF; proinflammatory cytokines; soluble receptors.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Model for pathogenesis of periodontitis
Figure 2
Figure 2
Mechanism of action of cytokines
Figure 3
Figure 3
Mechanism for cytokine-receptor interaction
See this image and copyright information in PMC

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