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Review
. 2011 May;82(5):618-27.
doi: 10.1007/s00115-010-2989-5.

[Genetic and brain structure anomalies in autism spectrum disorders. Towards an understanding of the aetiopathogenesis?]

[Article in German]
T Nickl-Jockschat  1 , T M Michel
Affiliations
Review

[Genetic and brain structure anomalies in autism spectrum disorders. Towards an understanding of the aetiopathogenesis?]

[Article in German]
T Nickl-Jockschat et al. Nervenarzt. 2011 May.

Abstract

Autism spectrum disorders (ASD) are pervasive development disorders with high heritability and an as yet unclear aetiology. So far molecular genetic research was able to identify several candidate genes for the disorder which are functionally linked to neurotransmission and neuronal migration, cortical organisation and synaptic plasticity. MRI studies repeatedly showed a higher total brain volume for ASD patients. The volume increase was most pronounced for the frontal and the temporal lobes and peaked in early childhood. A combination of molecular genetic and structural imaging research appears promising for a further characterization of ASD aetiology.

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References

    1. J Child Neurol. 2005 Jan;20(1):34-41 - PubMed
    1. Am J Hum Genet. 2008 Jan;82(1):165-73 - PubMed
    1. J Neurochem. 2002 Jun;81(5):903-10 - PubMed
    1. Mol Psychiatry. 2005 Jun;10(6):563-71 - PubMed
    1. Mol Psychiatry. 2002;7(3):311-6 - PubMed

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