Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997;5(5):341-6.
doi: 10.1002/(SICI)1097-0193(1997)5:5<341::AID-HBM2>3.0.CO;2-3.

In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging

E M Haacke  1 , S Lai, J R Reichenbach, K Kuppusamy, F G Hoogenraad, H Takeichi, W Lin
Affiliations

In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging

E M Haacke et al. Hum Brain Mapp. 1997.

Abstract

A novel noninvasive magnetic resonance imaging (MRI) method was developed to determine in vivo blood oxygen saturation and its changes during motor cortex activation in small cerebral veins. Specifically, based on susceptibility measurements in the resting states, pial veins were found to have a mean oxygen saturation of Yrest=0.544+/-0.029 averaged over 14 vessels in 5 volunteers. During activation, susceptibility measurements revealed an oxygen saturation change of DeltaYsusc=0.14+/-0.02. Independent evaluation from blood flow velocity measurements yielded a value of DeltaYflow=0.14+/-0.04 for this change. These results validate the blood oxygenation level-dependent (BOLD) model in functional MRI (fMRI).

PubMed Disclaimer

LinkOut - more resources