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. 2010 Jun 21;23(6):1001-8.
doi: 10.1021/tx100056m.

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention

Stephen S Hecht  1 , Jian-Min Yuan, Dorothy Hatsukami
Affiliations

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention

Stephen S Hecht et al. Chem Res Toxicol. .

Abstract

Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.

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Figures

Figure 1
Figure 1
Structures of the biomarkers.
See this image and copyright information in PMC

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