Review
doi: 10.2174/138955710791185127.
Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo
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- PMID: 20408797
- DOI: 10.2174/138955710791185127
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Review
Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo
Mini Rev Med Chem.
2010 Feb.
Abstract
Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo.
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