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Case Reports
. 2010 May;16(5):850-2.
doi: 10.3201/eid1605.091271.

Adenovirus 36 DNA in adipose tissue of patient with unusual visceral obesity

Behrouz Salehian  1 , Stephen J Forman, Fouad R Kandeel, Denise E Bruner, Jia He, Richard L Atkinson
Affiliations
Case Reports

Adenovirus 36 DNA in adipose tissue of patient with unusual visceral obesity

Behrouz Salehian et al. Emerg Infect Dis. 2010 May.

Abstract

Massive adipose tissue depositions in the abdomen and thorax sufficient to interfere with respiration developed in a patient with multiple medical problems. Biopsy of adipose tissue identified human adenovirus 36 (Adv 36) DNA. Adv 36 causes adipogenesis in animals and humans. Development of massive lipomatosis may be caused by Adv 36.

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Figures

Figure 1
Figure 1
Computed tomography scans of the patient, showing marked visceral adipose tissue in the abdomen (A) and thorax (B). Diffuse intrabadominal, retroperitoneal lipomatosis, and herniation of the mediastinum can be seen through the esophageal hiatus. Intrapericardial adipose infiltration and adipose tissue bilaterally are seen within the pleura.
Figure 2
Figure 2
HaeIII digestion of adenovirus 36 (Adv 36) DNA PCR products of the patient. Lane 1, molecular size marker; lane 2, HaeIII digest of Adv 36 DNA; lane 3, undigested Adv 36 DNA.
See this image and copyright information in PMC

References

    1. Dhurandhar NV, Israel BA, Kolesar JM, Mayhew GF, Cook ME, Atkinson RL. Increased adiposity in animals due to a human virus. Int J Obes Relat Metab Disord. 2000;24:989–96. 10.1038/sj.ijo.0801319 - DOI - PubMed
    1. Dhurandhar NV, Israel BA, Kolesar JM, Mayhew G, Cook ME, Atkinson RL. Transmissibility of adenovirus induced adiposity in a chicken model. Int J Obes Relat Metab Disord. 2001;25:990–6. 10.1038/sj.ijo.0801668 - DOI - PubMed
    1. Dhurandhar NV, Whigham LD, Abbott DH, Schultz-Darken NJ, Israel BA, Bradley SM, et al. Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys. J Nutr. 2002;132:3155–60. - PubMed
    1. Atkinson RL, Dhurandhar NV, Allison DB, Bowen RL, Israel BA, Albu JB, et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. Int J Obes (Lond). 2005;29:281–6. 10.1038/sj.ijo.0802830 - DOI - PubMed
    1. Atkinson RL, Lee I, Shin HJ, He J. Human adenovirus-36 antibody status is associated with obesity in children. Int J Pediatr Obes. 2009;10:1–4. 10.1080/17477160903111789 - DOI - PubMed

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