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Case Reports
. 2010 May;16(5):863-5.
doi: 10.3201/eid1605.091815.

Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus

Simona Puzelli  1 , Marzia Facchini, Domenico Spagnolo, Maria A De Marco, Laura Calzoletti, Alessandro Zanetti, Roberto Fumagalli, Maria L Tanzi, Antonio Cassone, Giovanni Rezza, Isabella Donatelli; Surveillance Group for Pandemic A H1N1 2009 Influenza Virus in Italy
Collaborators, Affiliations
Case Reports

Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus

Simona Puzelli et al. Emerg Infect Dis. 2010 May.

Abstract

A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.

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Figures

Figure
Figure
Phylogenetic relationships of hemagglutinin (HA) 1 sequences of pandemic (H1N1) 2009 viruses in Italy obtained from the National Influenza Centre (NIC)–Istituto Superiore di Sanità (ISS) and the National Center for Biotechnology Information. The NIC-ISS sequences are in italics. Isolates from the index case-patient and his father are indicated in boldface. Amino acid mutations of interest in this study are reported on the nodes. All the NIC sequences obtained in the present study were deposited in the GenBank database under the following accession numbers: (hemagglutinin sequences) GU451262–GU451280; GU576500–GU576502; GU576504; GU576506; GU576508; GU576510; GU576512; GU576514-GU57615; GU576517; GU576519; GU576521-GU576522; GU576524; GU576526-GU576527; GU576529; GU576531-GU576532; GU576534; GU576536-GU576540; GU585403–GU585443; (neuraminidase sequences) GU936490-GU936491. Scale bar indicates proportion of nucleotide substitutions per site.
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References

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