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Meta-Analysis
. 2010 Apr 22;362(16):1547-50.
doi: 10.1056/NEJMc0910050.

Failure to validate association between 12p13 variants and ischemic stroke

International Stroke Genetics Consortium; Wellcome Trust Case-Control Consortium 2
Collaborators
Meta-Analysis

Failure to validate association between 12p13 variants and ischemic stroke

International Stroke Genetics Consortium et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Associations between Single-Nucleotide Polymorphisms (SNPs) and Ischemic Strokes in Persons of European Ancestry, According to Study
The forest plots show the odds ratios for the association between ischemic strokes and the minor allele (A) of both SNPs. No risk effect of these alleles was detected for either SNP. Data from 8915 persons with ischemic strokes are shown. The comparison group is 30,510 stroke-free controls. Individual studies (blue boxes) are plotted against the individual effect sizes (odds ratios). The red diamonds indicate overall odds ratios. The size of the blue boxes indicates study-specific weights for the meta-analysis. Horizontal lines indicate 95% confidence intervals. The dashed vertical line shows the lack of any effect on the risk of stroke (odds ratio, 1.0). ESS denotes Edinburgh Stroke Study, GCNKSS Greater Cincinnati/Northern Kentucky Stroke Study, ISGS Ischemic Stroke Genetics Study, MCISS Middlesex County Ischemic Stroke Study, MGH Massachusetts General Hospital, MIGen Myocardial Infarction Genetics Consortium, SWISS Siblings with Ischemic Stroke Study, UMD-SPYAS University of Maryland Stroke Prevention in the Young Study, VISP Vitamin Intervention for Stroke Prevention Trial, WGHS Women’s Genome Health Study, WTCCC2:GER Wellcome Trust Case–Control Consortium 2, German data, and WTCCC2:UK Wellcome Trust Case–Control Consortium 2, United Kingdom data.
Figure 2
Figure 2. Associations between Single-Nucleotide Polymorphisms (SNPs) and Atherothrombotic Strokes in Persons of European Ancestry, According to Study
The forest plots show the odds ratios for the association between atherothrombotic strokes and the minor allele (A) of both SNPs. No risk effect of these alleles was detected for either SNP. Data from 2235 persons with atherothrombotic strokes are shown. The comparison group is 30,510 stroke-free controls. Individual studies (blue boxes) are plotted against the individual effect sizes (odds ratios). The red diamonds indicate overall odds ratios. The size of the blue boxes indicates study-specific weights for the meta-analysis. Horizontal lines indicate 95% confidence intervals. The dashed vertical line shows the lack of any effect on the risk of stroke (odds ratio, 1.0).
See this image and copyright information in PMC

Comment on

  • Genomewide association studies of stroke.
    Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K, Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, van Duijn CM, Breteler MM, Longstreth WT Jr, Wolf PA. Ikram MA, et al. N Engl J Med. 2009 Apr 23;360(17):1718-28. doi: 10.1056/NEJMoa0900094. Epub 2009 Apr 15. N Engl J Med. 2009. PMID: 19369658 Free PMC article.

References

    1. Ikram MA, Seshadri S, Bis JC, et al. Genomewide association studies of stroke. N Engl J Med. 2009;360:1718–1728. - PMC - PubMed
    1. Adams HP, Jr, Bendixen BH, Kappelle LJ, et al. Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. Stroke. 1993;24:35–41. - PubMed
    1. Zeggini E, Ioannidis JP. Meta-analysis in genome-wide association studies. Pharmacogenomics. 2009;10:191–201. - PMC - PubMed

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