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. 2010 Mar 22;8(3):810-34.
doi: 10.3390/md8030810.

Cyclodepsipeptides from marine sponges: natural agents for drug research

Gowri Shankar Bagavananthem Andavan  1 , Rosa Lemmens-Gruber
Affiliations

Cyclodepsipeptides from marine sponges: natural agents for drug research

Gowri Shankar Bagavananthem Andavan et al. Mar Drugs. .

Abstract

A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived moieties. Papuamides are representatives of a class of marine sponge derived cyclic depsipeptides, including callipeltin A, celebesides A and B, homophymine A, mirabamides, microspinosamide, neamphamide A and theopapuamides. They are thought to have cytoprotective activity against HIV-1 in vitro by inhibiting viral entry. Jasplakinolide, a representative member of marine sponge-derived cyclodepsipeptides that include arenastatin A, geodiamolides, homophymines, spongidepsin and theopapuamides, is a potent inducer of actin polymerization in vitro. Although actin dynamics is essential for tumor metasasis, no actin targeting drugs have been used in clinical trials due to their severe cytotoxicity. Nonetheless, the actin cytoskeleton remains a potential target for anti-cancer drug development. These features imply the use of cyclodepsipeptides as molecular models in drug research.

Keywords: HIV entry inhibitors; actin polymerisation; cyclodepsipeptides; jasplakinolide; papuamides.

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Figures

Figure 1
Figure 1
Structure of papuamide A.
Figure 2
Figure 2
Structure of jasplakinolide.
Figure 3
Figure 3
Structure of arenastatin.
See this image and copyright information in PMC

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