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. 2010 Aug;18(8):1099-106.
doi: 10.1007/s00520-010-0882-1. Epub 2010 Apr 22.

A systematic review of bisphosphonate osteonecrosis (BON) in cancer

Cesar Augusto Migliorati  1 , Sook-Bin Woo, Ian Hewson, Andrei Barasch, Linda S Elting, Fred K L Spijkervet, Michael T Brennan; Bisphosphonate Osteonecrosis Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO)
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A systematic review of bisphosphonate osteonecrosis (BON) in cancer

Cesar Augusto Migliorati et al. Support Care Cancer. 2010 Aug.

Abstract

Purpose: This systematic review aims to examine the prevalence of bisphosphonate osteonecrosis (BON) in the cancer population, prevention and treatment protocols, and quality of life issues.

Methods: A search of MEDLINE/PubMed and EMBASE form October 2003 to December 31, 2008 was conducted with the objective of identifying publications that contained original data regarding BON.

Results: A total of 28 publications fulfilled inclusion criteria, but only 22 were used for prevalence analysis. No randomized controlled clinical trials, meta-analysis, or quality of life papers were found that contained information regarding either prevalence or treatment protocols for the management of BON. The overall weighted prevalence of BON included a sample of 39,124 patients with a mean weighted prevalence of 6.1%. The weighted prevalence was 13.3% for studies with documented follow-up with a sample size of 927 individuals. The weighted prevalence in studies with undocumented follow-up was 0.7% in a sample of 8,829 chart reviews. Epidemiological studies evaluated a total of 29,368 individual records, and the weighted BON prevalence was 1.2%.

Conclusions: High-quality studies are needed to accurately characterize the prevalence of BON, and to determine effective treatment protocols.

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References

    1. J Oral Maxillofac Surg. 2004 May;62(5):527-34 - PubMed
    1. Clin Cancer Res. 2008 Apr 15;14(8):2387-95 - PubMed
    1. J Oral Maxillofac Surg. 2008 May;66(5):839-47 - PubMed
    1. Laryngoscope. 2006 Jan;116(1):115-20 - PubMed
    1. Leuk Lymphoma. 2007 Jan;48(1):56-64 - PubMed

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