Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009:(73):203-13.
doi: 10.1007/978-3-211-92660-4_16.

Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta

Nina Eriksen  1 , Anette Kirstine Stark, Bente Pakkenberg
Affiliations
Review

Age and Parkinson's disease-related neuronal death in the substantia nigra pars compacta

Nina Eriksen et al. J Neural Transm Suppl. 2009.

Abstract

During aging, decline in memory and cognitive abilities as well as motor weakening is of great concern. The dopaminergic system mediates some aspects of manual dexterity, in addition to cognition and emotion, and may be especially vulnerable to aging. A common neurodegenerative disorder of this system, Parkinson's disease, is characterized by a selective, progressive loss of dopaminergic neurons in the substantia nigra pars compacta. This review includes studies quantifying age and Parkinson's-related changes of the substantia nigra, with emphasis on stereological studies performed in the substantia nigra pars compacta.

PubMed Disclaimer

LinkOut - more resources