Antisocial networking in T helper cells
- PMID: 20412760
- DOI: 10.1016/j.immuni.2010.04.006
Antisocial networking in T helper cells
Abstract
T helper cell differentiation is controlled by a network of transcription factors. In this issue of Immunity, Yagi et al. (2010) describe the opposing effects of transcription factors Runx3 and GATA3 in the network promoting T helper 1 cell development.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.Immunity. 2010 Apr 23;32(4):507-17. doi: 10.1016/j.immuni.2010.04.004. Epub 2010 Apr 15. Immunity. 2010. PMID: 20399120 Free PMC article.
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