[Effects of obsidan on hemodynamic indices and clinical manifestations of angina pectoris in patients with ischemic heart disease during psychoemotional stress]

Abstract

Obsidan was tested for effects on psychoemotional stress (PES) tolerance in 37 patients with coronary heart disease concurrent with angina pectoris. During PES testing, the course treatment of obsidan versus placebo resulted in a significant decrease in the pulse-pressure index by significantly bringing down heart rate. With this, blood pressure remained unchanged. The patients who were highly responsive to PES, as evidenced by heart rate measurement, showed a high rise in systolic and diastolic blood pressure when they were taking obsidan. The frequency of positive tests was 48.7% before obsidan therapy and 8.1% during its therapy; that was 29.8 and 8.1%, respectively, when the objective criterion for myocardial ischemia was used as ECG ST-segment displacement.