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. 2010 May-Jun;58(3):199-203.
doi: 10.4103/0301-4738.62643.

Profile of angle closure in a tertiary care center in north India

Parul Ichhpujani  1 , Surinder S Pandav, Aparna Ramasubramanian, Sushmita Kaushik
Affiliations

Profile of angle closure in a tertiary care center in north India

Parul Ichhpujani et al. Indian J Ophthalmol. 2010 May-Jun.

Abstract

Purpose: To study the demographic and clinical profile of the types of primary angle closure patients presenting at a tertiary care center in North India.

Materials and methods: Clinic records of patients diagnosed as primary angle closure were reviewed. International Society of Geographical and Epidemiological Ophthalmology (ISGEO) classification scheme was used to categorize patients. Demographic and clinical data including prior management was collected and analyzed. Main Outcome measures were age, sex, symptomatology, best corrected visual acuity (BCVA), intraocular pressure (IOP), gonioscopy, optic disc assessment and visual field defects. Logistic regression model and receiver operating curve (ROC) were calculated for predictors of type of glaucoma.

Results: Eight hundred and fourteen patients (1603 eyes; males: 380, females: 434) were diagnosed to have various subtypes of angle closure. Mean (+/-SD) age at presentation was significantly higher for males (57.57 +/- 11.62 years) as compared to females (53.64 +/- 10.67 years) ( P < 0001). Primary angle closure glaucoma (PACG) was most frequently diagnosed subtype (49.38%) followed by Primary angle closure (PAC) (39.68%) and Primary angle closure suspect (PACS) (10.93%) respectively. The three subtypes differed significantly among their mean IOP (on ANOVA, F = 14.04; P < 0001 using Greenhouse-Geisser correction). Univariate analysis was done to find significant predictors for the outcome of PACG. Logistic regression model and ROC containing the significant predictors yielded a very high AUC of 0.93 with strong discriminatory ability for PACG.

Conclusion: In our hospital-based study, the significant predictors for the outcome of PACG included male gender, diminution of vision, the presence of pain and worsening grades of BCVA. Nearly half of PACG presented with advanced disease. In spite of one-third of the patients being diagnosed as angle closure prior to referral, only 8.34% had iridotomy (laser or surgical) done.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Subtypes of angle closure stratified by gender
Figure 2
Figure 2
Visual acuity range of subtypes
Figure 3
Figure 3
Receiver operating curve showing area under curve (0.93) for outcome of primary angle closure glaucoma
See this image and copyright information in PMC

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