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Review
. 2010 Jun;59(2):125-35.
doi: 10.2332/allergolint.10-RAI-0190. Epub 2010 Apr 24.

IL-1 and Allergy

Aya Nambu  1 , Susumu Nakae
Affiliations
Free article
Review

IL-1 and Allergy

Aya Nambu et al. Allergol Int. 2010 Jun.
Free article

Abstract

IL-1 is a well-characterized proinflammatory cytokine that is involved in host defense and autoimmune diseases. IL-1 can promote activation of T cells, including Th1 cells, Th2 cells and Th17 cells, and B cells, suggesting that IL-1 may contribute to the development of various types of T-cell-mediated diseases. This report reviews and discusses the role of IL-1 in the pathogenesis of allergic diseases based on studies using IL-1-related gene-deficient mice.

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