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. 2010 Jul;32(5):423-6.
doi: 10.1097/DAD.0b013e3181c4340a.

Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly

David D Weedon  1 , Jonathan Malo, David Brooks, Richard Williamson
Affiliations

Squamous cell carcinoma arising in keratoacanthoma: a neglected phenomenon in the elderly

David D Weedon et al. Am J Dermatopathol. 2010 Jul.

Abstract

Keratoacanthoma is a unique clinicopathologic entity with a behavior and clinical outcome that differs markedly from that of squamous cell carcinoma. The development of squamous cell carcinoma in a keratoacanthoma alluded to by Rook and Whimster in 1979 and by Reed in 1993 was confirmed by Sánchez Yus et al in 2000. We found this phenomenon in 5.7% of keratoacanthomas in a series of 3465 cases. Its incidence in patients older than 90 years was 13.9%. The incidence of perineural invasion in this series of keratoacanthomas was 0.2%.

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