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. 1991 May 25;19(10):2609-13.

Coincident sequence cloning

A J Brookes  1 , D J Porteous
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Free PMC article

Coincident sequence cloning

A J Brookes et al. Nucleic Acids Res. .
Free PMC article

Abstract

We describe a novel method, Coincident Sequence Cloning (CSC), which permits the selective recovery of common sequences shared between two complex and partially coincident DNA mixtures. We evaluate this method by integrating human DNA with DNA from a mouse-human somatic cell hybrid, and we recover exclusively human DNA products which are all represented in the hybrid genome. CSC strategies should be useful in addressing many highly complex problems in genome analysis.

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