Mitochondria as pharmacological targets
- PMID: 20423336
- PMCID: PMC2874844
- DOI: 10.1111/j.1476-5381.2010.00706.x
Mitochondria as pharmacological targets
Abstract
In the last decade, mitochondria have provided a vast area of research for the pharmacologist, with a wealth of potential targets for drug action. Correct target identification and subsequent pharmacological manipulation might greatly help in the prevention and/or treatment of a number of the most prevalent diseases of our time including cancer, neurodegenerative disease and myocardial infarction. This is a commentary to accompany the publication of three papers in this issue of the BJP by Kurz et al., Pravdic et al. and Puerta et al. on different aspects of pharmacology involving mitochondria.
Comment on
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The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by beta-amyloid peptide.Br J Pharmacol. 2010 May;160(2):246-57. doi: 10.1111/j.1476-5381.2010.00656.x. Epub 2010 Mar 9. Br J Pharmacol. 2010. PMID: 20218980 Free PMC article.
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Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion.Br J Pharmacol. 2010 May;160(2):220-32. doi: 10.1111/j.1476-5381.2010.00698.x. Br J Pharmacol. 2010. PMID: 20423337 Free PMC article.
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Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.Br J Pharmacol. 2010 May;160(2):233-45. doi: 10.1111/j.1476-5381.2010.00663.x. Br J Pharmacol. 2010. PMID: 20423338 Free PMC article.
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