Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;33(8):1699-705.
doi: 10.2337/dc09-2302. Epub 2010 Apr 27.

Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes

Joline W J Beulens  1 , Daphne L van der A, Diederick E Grobbee, Ivonne Sluijs, Annemieke M W Spijkerman, Yvonne T van der Schouw
Affiliations

Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes

Joline W J Beulens et al. Diabetes Care. 2010 Aug.

Abstract

Objective: To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.

Research design and methods: We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20-70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records.

Results: During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66-0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87-1.00) for each 10-microg increment in the multivariate model.

Conclusions: This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Association between phylloquinone intake and risk of type 2 diabetes modeled continuously using splines; HR (——) with 95% CI in gray.
See this image and copyright information in PMC

References

    1. Bolton-Smith C, Price RJ, Fenton ST, Harrington DJ, Shearer MJ: Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr 2000;83:389–399 - PubMed
    1. Schurgers LJ, Vermeer C: Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations Haemostasis 2000;30:298–307 - PubMed
    1. Cranenburg EC, Schurgers LJ, Vermeer C., Vitamin K: The coagulation vitamin that became omnipotent. Thromb Haemost 2007;98:120–125 - PubMed
    1. Ferron M, Hinoi E, Karsenty G, Ducy P: Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 2008;105:5266–5270 - PMC - PubMed
    1. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B: Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 2009;94:827–832 - PMC - PubMed

Publication types