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. 1978 Jan;13(1):124-7.
doi: 10.1128/AAC.13.1.124.

Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus

B Fridlender, N Chejanovsky, Y Becker

Deoxyribonucleic acid polymerase of wild-type and phosphonoacetic acid-resistant mutant of herpes simplex virus

B Fridlender et al. Antimicrob Agents Chemother. 1978 Jan.

Abstract

The phosphonacetic acid (PAA)-susceptible deoxyribonucleic acid (DNA) polymerase of herpes simplex virus type 1 was partially purified and isolated in sucrose gradients and on double-strand DNA cellulose columns. The DNA polymerase isolated from cells infected with the PAA-resistant mutant had the same molecular weight as the wild-type enzyme (140,000 to 149,000) but was consistently more resistant to PAA.

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