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Review
. 2010 Feb;12(1):5-9.
doi: 10.1007/s11906-009-0083-9.

Recent advances in genetics of the spontaneously hypertensive rat

Michal Pravenec  1 , Theodore W Kurtz
Affiliations
Review

Recent advances in genetics of the spontaneously hypertensive rat

Michal Pravenec et al. Curr Hypertens Rep. 2010 Feb.

Abstract

The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and associated metabolic disturbances. Multiple quantitative trait loci associated with hemodynamic and metabolic parameters have been mapped in the SHR. Recently, it has become possible to identify some of the specific quantitative trait gene (QTG) variants that underlie quantitative trait loci linked to complex cardiovascular and metabolic traits in SHR related strains. Recombinant inbred strains derived from SHR and Brown Norway progenitors, together with SHR congenic and transgenic strains, have proven useful for establishing the identity of several QTGs in SHR models. It is anticipated that the combined use of linkage analyses and gene expression profiles, together with the recently available genome sequences of both the SHR and Brown Norway strains and new methods for manipulating the rat genome, will soon accelerate progress in identifying QTGs for complex traits in SHR-related strains.

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Figures

Fig. 1
Fig. 1
Transgenic spontaneously hypertensive rats (SHRs) derived with the Sleeping Beauty RMCE/Venus transposon vectors. F1 rats were obtained by mating the RMCE/Venus SHR line 80 with three insertional sites on chromosomes 2, 4, and 16 with the SHR progenitor. The different shades of green reflect segregation of the transgenes in F1 rats (Izsvak, Mates, Landa, Pravenec, unpublished results)
See this image and copyright information in PMC

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