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Review
. 2007 Oct;2(4):278-82.
doi: 10.1007/s11899-007-0038-7.

Large granular lymphocyte leukemia

Affiliations
Review

Large granular lymphocyte leukemia

Lubomir Sokol et al. Curr Hematol Malig Rep. 2007 Oct.

Abstract

Clonal diseases of large granular lymphocytes (LGLs) represent a spectrum of clinically rare lymphoproliferative malignancies arising from either mature T-cell (CD3(+)) or natural killer (NK)-cell (CD3(-)) lineages. The clinical behavior of these disorders ranges from indolent to very aggressive. Patients with symptomatic indolent T-cell or NK-cell LGL leukemia are usually treated with immunosuppressive therapies; in contrast, aggressive T-cell or NK-cell LGL leukemias require intensive chemotherapy regimens. Novel targeted therapies are currently being tested in clinical studies.

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References

    1. Blood. 1998 May 1;91(9):3372-8 - PubMed
    1. Br J Haematol. 2002 Mar;116(3):598-600 - PubMed
    1. Blood. 1996 Feb 15;87(4):1474-83 - PubMed
    1. Blood. 1993 Jul 1;82(1):1-14 - PubMed
    1. Ann Intern Med. 1985 Feb;102(2):169-75 - PubMed

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