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Review
. 2010 Jun;22(3):397-401.
doi: 10.1016/j.coi.2010.03.007. Epub 2010 Apr 27.

Role of PD-1 in regulating acute infections

Keturah E Brown  1 , Gordon J Freeman, E John Wherry, Arlene H Sharpe
Affiliations
Review

Role of PD-1 in regulating acute infections

Keturah E Brown et al. Curr Opin Immunol. 2010 Jun.

Abstract

While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.

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Conflict of interest statement

Conflicts of interest

GJF, AHS and EJW have patents and receive patent royalties related to PD-1.

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