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Comment
. 2010 May;42(5):366-8.
doi: 10.1038/ng0510-366.

Chipping away at the genetics of smoking behavior

Christopher I Amos  1 , Margaret R Spitz, Paul Cinciripini
Affiliations
Comment

Chipping away at the genetics of smoking behavior

Christopher I Amos et al. Nat Genet. 2010 May.

Abstract

Three large consortia present comprehensive analyses that identify genetic factors influencing smoking initiation, intensity and cessation. The genetic architecture of these three phases of smoking behavior appears to be largely distinct.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare competing financial interests: details accompany the full-text HTML version of the paper at http://www.nature.com/naturegenetics/.

Figures

Figure 1
Figure 1
Smoking behavior as a multistep process with genetic influences. Nonsmoking individuals (those who have never smoked) may begin smoking (smoking initiation). At that point, they may become dependent upon cigarettes, and they are classified as having smoked (ever-smokers) once they have consumed 100 or more cigarettes. The TAG consortium report that variants at the BDNF locus influence smoking initiation. A region on chromosome 15 encompassing the nicotinic receptor subunit genes CHRNA5, CHRNA3 and CHRNB4 was associated with cigarettes consumed per day (CPD), a measure of smoking dependence–. The TAG and ENGAGE consortia also identified the CHRNA6–CHRNB3 cluster on chromosome 8p11, as well as loci found near CYP2A6 on 19q13 and in a region containing a noncoding RNA on chromosome 10q23, as associated with CPD,. For smoking cessation, the TAG consortium identified a region on chromosome 9 near the gene encoding dopamine β-hydroxylase (DBH). Further studies are needed to define the specific genes and causal variants in these regions.
See this image and copyright information in PMC

Comment on

  • Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.
    Thorgeirsson TE, Gudbjartsson DF, Surakka I, Vink JM, Amin N, Geller F, Sulem P, Rafnar T, Esko T, Walter S, Gieger C, Rawal R, Mangino M, Prokopenko I, Mägi R, Keskitalo K, Gudjonsdottir IH, Gretarsdottir S, Stefansson H, Thompson JR, Aulchenko YS, Nelis M, Aben KK, den Heijer M, Dirksen A, Ashraf H, Soranzo N, Valdes AM, Steves C, Uitterlinden AG, Hofman A, Tönjes A, Kovacs P, Hottenga JJ, Willemsen G, Vogelzangs N, Döring A, Dahmen N, Nitz B, Pergadia ML, Saez B, De Diego V, Lezcano V, Garcia-Prats MD, Ripatti S, Perola M, Kettunen J, Hartikainen AL, Pouta A, Laitinen J, Isohanni M, Huei-Yi S, Allen M, Krestyaninova M, Hall AS, Jones GT, van Rij AM, Mueller T, Dieplinger B, Haltmayer M, Jonsson S, Matthiasson SE, Oskarsson H, Tyrfingsson T, Kiemeney LA, Mayordomo JI, Lindholt JS, Pedersen JH, Franklin WA, Wolf H, Montgomery GW, Heath AC, Martin NG, Madden PA, Giegling I, Rujescu D, Järvelin MR, Salomaa V, Stumvoll M, Spector TD, Wichmann HE, Metspalu A, Samani NJ, Penninx BW, Oostra BA, Boomsma DI, Tiemeier H, van Duijn CM, Kaprio J, Gulcher JR; ENGAGE Consortium; McCarthy MI, Peltonen L, Thorsteinsdottir U, Stefansson K. Thorgeirsson TE, et al. Nat Genet. 2010 May;42(5):448-53. doi: 10.1038/ng.573. Epub 2010 Apr 25. Nat Genet. 2010. PMID: 20418888 Free PMC article.
  • Meta-analysis and imputation refines the association of 15q25 with smoking quantity.
    Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L, Berrettini W, Knouff CW, Yuan X, Waeber G, Vollenweider P, Preisig M, Wareham NJ, Zhao JH, Loos RJ, Barroso I, Khaw KT, Grundy S, Barter P, Mahley R, Kesaniemi A, McPherson R, Vincent JB, Strauss J, Kennedy JL, Farmer A, McGuffin P, Day R, Matthews K, Bakke P, Gulsvik A, Lucae S, Ising M, Brueckl T, Horstmann S, Wichmann HE, Rawal R, Dahmen N, Lamina C, Polasek O, Zgaga L, Huffman J, Campbell S, Kooner J, Chambers JC, Burnett MS, Devaney JM, Pichard AD, Kent KM, Satler L, Lindsay JM, Waksman R, Epstein S, Wilson JF, Wild SH, Campbell H, Vitart V, Reilly MP, Li M, Qu L, Wilensky R, Matthai W, Hakonarson HH, Rader DJ, Franke A, Wittig M, Schäfer A, Uda M, Terracciano A, Xiao X, Busonero F, Scheet P, Schlessinger D, St Clair D, Rujescu D, Abecasis GR, Grabe HJ, Teumer A, Völzke H, Petersmann A, John U, Rudan I, Hayward C, Wright AF, Kolcic I, Wright BJ, Thompson JR, Balmforth AJ, Hall AS, Samani NJ, Anderson CA, Ahmad T, Mathew CG, Parkes M, Satsangi J, Caulfield M, Munroe PB, Farrall M, Dominiczak A, Worthington J, Thomson W, Eyre S, Barton A; Wellcome Trust Case Control Consortium; Mooser V, Francks C, Marchini J. Liu JZ, et al. Nat Genet. 2010 May;42(5):436-40. doi: 10.1038/ng.572. Epub 2010 Apr 25. Nat Genet. 2010. PMID: 20418889 Free PMC article.
  • Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
    Tobacco and Genetics Consortium. Tobacco and Genetics Consortium. Nat Genet. 2010 May;42(5):441-7. doi: 10.1038/ng.571. Epub 2010 Apr 25. Nat Genet. 2010. PMID: 20418890 Free PMC article.

References

    1. Li MD Curr. Psychiatry Rep 8, 158–164 (2006). - PubMed
    1. Thorgeirsson TE et al. Nat. Genet 42, 448–453 (2010). - PMC - PubMed
    1. Liu JZ et al. Nat. Genet 42, 436–440 (2010). - PMC - PubMed
    1. TAG Consortium. Nat. Genet 42, 441–447 (2010).
    1. Fanous S, Hammer RP Jr. & Nikulina EM Neuroscience 10.1016/j.neuroscience.2010.02.064 (3 March 2010). - DOI - PMC - PubMed