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. 2010 Jul 12;12(4):541-7.
doi: 10.1021/cc100052j.

Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents

Chunwei Cheng  1 , Lili Pan, Yi Chen, Hao Song, Yong Qin, Rongshi Li
Affiliations

Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents

Chunwei Cheng et al. J Comb Chem. .

Erratum in

  • J Comb Chem. 2010 Nov 8;12(6):900

Abstract

The first total synthesis of marine natural product, (+/-)-marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.

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