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Review
. 2010 Aug;15(5):379-99.
doi: 10.3109/13547501003797664.

Polymorphisms in DNA damage response genes and head and neck cancer risk

Rafael E Flores-Obando  1 , Susanne M Gollin, Camille C Ragin
Affiliations
Review

Polymorphisms in DNA damage response genes and head and neck cancer risk

Rafael E Flores-Obando et al. Biomarkers. 2010 Aug.

Abstract

Background: Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.

Objective: To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.

Method: A meta-analysis including 30 case-control studies was performed.

Results: Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.

Conclusion: Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.

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Conflict of interest statement

Declaration of interest: The authors have no commercial association that might pose or create a conflict of interest with the information presented this manuscript.

Figures

Figure 1
Figure 1
Published case-control studies that included only oral cavity cases in Asian populations show a significant association of the XRCC1 exon 6 codon 194 (C/T) heterozygous variant and the risk of oral cavity cancer. The shaded boxes represent the study-specific odds ratio, and the horizontal lines represent the confidence intervals; the size of each box depict how each study is weighted in the analysis, the diamond represents the meta-OR and its width represents the CI for the meta-OR.
Figure 2
Figure 2
(A) Published case-control studies show non-significant association of the XRCC1 exon 6 codon 194 (T/T) homozygous variant and the risk of head and neck cancer Caucasian populations. The shaded boxes represent the study-specific odds ratio, and the horizontal lines represent the confidence intervals; the size of the boxes depict how each study is weighted in the analysis, the diamond represents the meta-OR and its width represents the CI for the meta-OR. (B) Published case-control studies show a significant association of the XRCC1 exon 6 codon 194 (T/T) homozygous variant and the risk of head and neck cancer Asian populations. The shaded boxes represent the study-specific odds ratio, and the horizontal lines represent the confidence intervals; the size of the boxes depict how each study is weighted in the analysis, the diamond represents the meta-OR and its width represents the CI for the meta-OR.
See this image and copyright information in PMC

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