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Case Reports
. 2010 May-Jun;32(3):342.e1-3.
doi: 10.1016/j.genhosppsych.2009.07.010. Epub 2009 Sep 11.

A possible case of mixed mania due to neurosarcoidosis treated successfully with methylprednisolone and ziprasidone: another example of frontal-subcortical disinhibition?

David R Spiegel  1 , Christopher S Thomas, Pallav Shah, Kristin D Kent
Affiliations
Case Reports

A possible case of mixed mania due to neurosarcoidosis treated successfully with methylprednisolone and ziprasidone: another example of frontal-subcortical disinhibition?

David R Spiegel et al. Gen Hosp Psychiatry. 2010 May-Jun.

Abstract

Sarcoidosis is an idiopathic systemic granulomatous disease recognized by clinical and radiographic findings, which ultimately require histopathologic confirmation of noncaseating granulomas for a definitive diagnosis. Psychiatric manifestations occur in 20% of patient with neurosarcoidosis [http://dynaweb.ebscohost.com.chekov.evms.edu/Detail.aspx?id=306337&sid=bdce39cc-d2bd-4977-9e4d-786f2e768d57@sessionmgr4]. We present a case of suspected mixed mania due to neurosarcoidosis, with the manic symptoms responding early and robustly to ziprasidone.

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