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Comment
. 2010 Apr 29;115(17):3642-3.
doi: 10.1182/blood-2010-01-264564.

Meis1 maintains stemness signature in MLL-AF9 leukemia

Ashish R Kumar, Aaron L Sarver, Baolin Wu, John H Kersey
Comment

Meis1 maintains stemness signature in MLL-AF9 leukemia

Ashish R Kumar et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
Significant inhibition of ESC-like gene sets with Meis1 knockdown in murine MLL-AF9 leukemia. Expression of gene sets composed of core-ESC module, core-ESC module without proliferation-associated genes,, and another ESC-like gene set were compared across the dataset of control and Meis1-shRNA transduced murine MLL-AF9 leukemia cells using GSEA. Shown are the enrichment plots of GSEA analysis illustrating that the gene sets composed of core ESC module (A), core ESC module without the genes associated with proliferation (B), and the ECS-like signature (C) were all significantly inhibited with Meis1 knockdown (preranked analysis using Log2 fold change statistic, 1000 permutations, P < .001 for all analyses; results were similar when the paired t test statistic was used).
See this image and copyright information in PMC

Comment on

  • A role for MEIS1 in MLL-fusion gene leukemia.
    Kumar AR, Li Q, Hudson WA, Chen W, Sam T, Yao Q, Lund EA, Wu B, Kowal BJ, Kersey JH. Kumar AR, et al. Blood. 2009 Feb 19;113(8):1756-8. doi: 10.1182/blood-2008-06-163287. Epub 2008 Dec 24. Blood. 2009. PMID: 19109563 Free PMC article.

References

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