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. 2010 Jan;30(1):1-7.
doi: 10.4103/0973-3930.60001.

Pharmacological evaluation of "Glyoherb": A polyherbal formulation on streptozotocin-induced diabetic rats

Nima V Thakkar  1 , Jagruti A Patel
Affiliations

Pharmacological evaluation of "Glyoherb": A polyherbal formulation on streptozotocin-induced diabetic rats

Nima V Thakkar et al. Int J Diabetes Dev Ctries. 2010 Jan.

Abstract

In the present study, powdered suspension of 'Glyoherb'- sugar control granules, a polyherbal formulation (manufactured by Dhanvantri Guj. herb., Valasan, Anand, Gujarat, India) was evaluated for its antihyperglycemic, antihyperlipidemic and antioxidant effects against normal and streptozotocin-induced diabetic rats. Type I diabetes was induced when streptozotocin 70 mg/kg was administered as a single i.p. injection. After five days of streptozotocin injection, animals showing glycosuria (fasting blood sugar level >200 mg/dl) were considered as diabetic. Daily oral administration of 'Glyoherb' suspension in 200, 400 and 600 mg/kg doses for 28 days produced a dose-dependant decrease in blood glucose levels. It also produced a significant decrease in elevated serum triglyceride, cholesterol, VLDL, LDL, atherogenic index, serum urea, and creatinine and in antioxidant parameters in a dose dependant manner. Results were analyzed using one way ANOVA followed by Tukey's test. No significant changes were noticed in blood glucose, serum lipid levels and kidney parameters in normal rats treated with 'Glyoherb' suspension alone. The efficacy of 'Glyoherb' suspension as an antihyperglycemic, antihyperlipidemic and antioxidant agent in streptozotocin-induced diabetes was comparable to that of the standard drug Glibenclamide (5 mg/kg).

Keywords: Diabetes mellitus; glyoherb; hyperlipidemia; streptozotocin.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Effect of Glyoherb on serum creatinine levels in control and STZ induced diabetic rats (n = 6); Values are expressed as Mean ± S.E.M.; Statistical evaluation was done using ANOVA followed by Tukey's test.; *-Significantly different from normal control (P < 0.05); #-Significantly different from diabetic control (P < 0.05)
Figure 2
Figure 2
Effect of Glyoherb on serum urea levels in control and STZ induced diabetic rats (n = 6); Values are expressed as Mean ± S.E.M; Statistical evaluation was done using ANOVA followed by Tukey's test; *-Significantly different from normal control (P < 0.05); #-Significantly different from diabetic control (P < 0.05)
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References

    1. King H, Aubert RE, Herman WH. Global burden of diabetes 1995-2025. Diabetes Care. 1998;21:1414–31. - PubMed
    1. Kameswara Rao B, Giri R, Kesavalu MM, Rao A. Herbal medicine in the management of diabetes mellitus. Manphar Vaidhya Patrika. 1997;1:33–5.
    1. Cryer PE. Hypoglycemic agents. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison's principles of internal medicine. 15th ed. Vol 2. McGraw-Hill; 2001. pp. 2138–43.
    1. Davis SN, Granner DK. Insulin, oral hypoglycemic agents and endocrine pancreas. In: Gilman AG, Goodman LS, Rall TW, Murad F, editors. The pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill; 2001. pp. 1679–714.
    1. Winocour PH, Ishola M, Durrington PN. Validation of the friedewald's formula for the measurement of low density lipoprotein cholesterol in insulin dependant diabetes mellitus. Clin Chim Acta. 1989;179:79–83. - PubMed

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