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Review
. 1991 Feb;8(1):24-35.
doi: 10.1016/1050-3862(91)90005-c.

Analysis of genes and chromosomes by nonisotopic in situ hybridization

P Lichter  1 , A L Boyle, T Cremer, D C Ward
Affiliations
Free article
Review

Analysis of genes and chromosomes by nonisotopic in situ hybridization

P Lichter et al. Genet Anal Tech Appl. 1991 Feb.
Free article

Abstract

Nonisotopic in situ hybridization is a powerful tool to analyze the organization of complex genomes. Current approaches utilizing this technique for the analysis of linear and spatial genome organizations are presented. Clinical applications of these approaches, which open new avenues for diagnosis of disease-related chromosomal changes, are also discussed.

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