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Comment
. 2010 Apr 30;141(3):399-400.
doi: 10.1016/j.cell.2010.04.016.

Regulation of RNA polymerase II elongation by c-Myc

David H Price  1
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Free article
Comment

Regulation of RNA polymerase II elongation by c-Myc

David H Price. Cell. .
Free article

Abstract

The genome-wide mapping presented in this issue by Rahl et al. (2010) demonstrates how the transcription factor c-Myc interfaces with the machinery that controls RNA polymerase II elongation. These findings account for the ability of c-Myc to activate the expression of a large number of genes that promote rapid proliferation.

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  • c-Myc regulates transcriptional pause release.
    Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA. Rahl PB, et al. Cell. 2010 Apr 30;141(3):432-45. doi: 10.1016/j.cell.2010.03.030. Cell. 2010. PMID: 20434984 Free PMC article.

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