Guiding endosomal maturation
- PMID: 20434982
- DOI: 10.1016/j.cell.2010.04.013
Guiding endosomal maturation
Abstract
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
2010 Elsevier Inc. All rights reserved.
Comment on
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Identification of the switch in early-to-late endosome transition.Cell. 2010 Apr 30;141(3):497-508. doi: 10.1016/j.cell.2010.03.011. Cell. 2010. PMID: 20434987
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